Imidaz0[1,2-a] pyridine-6-carboxamide derivatives, their use...

Details Imidaz0[1,2-a] pyridine-6-carboxamide derivatives, their use... Imidaz0[1,2-a] pyridine-6-carboxamide derivatives, their use...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2758019

This invention relates to the manufacture of novel chemical compounds which have biological activity, particularly to novel chemical compounds that are cytotoxic against colon cancer cells and colon cancer cell lines. The manufacturing of said chemical compounds displaying anti-cancer properties employs the use of multi- component chemical reactions. The object of this invention is to manufacture and isolate analogues of imidazo[1,2-a]pyridine, namely compounds of Formula 1, which are cytotoxic against colon cancer cells, while concomitantly being relatively inactive against white blood cells. Formula 1 wherein, R is bromo, methyl, phenyl, nitro, hydrogen or an amide functional group; R1 is benzyl, 2,6-dimethylphenyl or cyclohexyl; and R2 is methoxy, benzyloxy or hydroxy.

L'invention porte sur la fabrication de nouveaux composés chimiques qui ont une activité biologique, notamment sur de nouveaux composés chimiques qui sont cytotoxiques contre des cellules de cancer du côlon et des lignées cellulaires de cancer du côlon. La fabrication de tels composés chimiques présentant des propriétés anticancéreuses emploie l'utilisation de réactions chimiques à multiples composants. L'objet de cette invention est de fabriquer et d'isoler des analogues d'imidazo[1,2-a]pyridine, c'est-à-dire des composés de Formule 1, qui sont cytotoxiques contre des cellules de cancer du côlon, tout en étant en même temps relativement inactifs contre les globules blancs. Formule 1, dans laquelle R est bromo, méthyle, phényle, nitro, hydrogène ou un groupe fonctionnel amide; R1 est benzyle, 2,6-diméthylphényle ou cyclohexyle; et R2 est méthoxy, benzyloxy ou hydroxy.

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