Imidazo [1,2-a] imidazoles, their acid addition salts,...

Details Imidazo [1,2-a] imidazoles, their acid addition salts,... Imidazo [1,2-a] imidazoles, their acid addition salts,...

C - Chemistry, Metallurgy

07

D

260/299

C07D 487/04 (2006.01)

Patent

CA 1115280

ABSTRACT Imidazo[1,2-a]imidazoles of general formula Image I (wherein R1, R2 and R3 independently represent hydrogen, fluorine, chlorine, bromine, methyl, methoxy or trifluoromethyl, but at least one of R1, R2 and R3 is other than hydrogen; R4 and R5 independently represent hydrogen or methyl) and pharmaceutically acceptable acid addition salts thereof. The compounds have been found to decrease heart beat frequency and may therefore be useful in the treatment of coronary diseases. Processes for the preparation of the compounds, and pharmaceutical compositions containing them, are described and exemplified.

330436

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