Imidazo (1,2-a)pyridin-3-yl-acetic acid hydrazides,...

C - Chemistry – Metallurgy – 07 – D

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C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2635802

The invention provides novel imidazo[1,2-a]pyridin- 3-yl-acetic acid hydrazides of formula (I) wherein R1, R2 and R3 have different meanings, and pharmaceutically acceptable salts, polymorphs, hydrates, tautomers, solvates and stereoisomers thereof. Compounds of formula (I) are useful for treating or preventing, in a human or non-human mammal, diseases associated with GABAA receptors modulation, anxiety, epilepsy, sleep disorders including insomnia, and for inducing sedation-hypnosis, anesthesia, sleep and muscle relaxation. The invention also provides synthetic processes for preparing said compounds.

La présente invention concerne de nouveaux hydrazides de l'acide imidazo[1,2-a]pyridin-3-yl-acétique de formule (I) où R1, R2 et R3 ont des valeurs différentes, ainsi que les sels de qualité pharmaceutique, les formes polymorphiques, les hydrates, les tautomères, les solvates et les stéréoisomères desdits hydrazides. Les composés de formule (I) peuvent être employés dans le traitement prophylactique ou thérapeutique, chez un humain ou un mammifère non humain, de maladies associées à la modulation des récepteurs GABAA, de l'anxiété, de l'épilepsie, de troubles du sommeil incluant l'insomnie, ainsi que pour induire une hypnose sédative, une anesthésie, le sommeil et la relaxation musculaire. La présente invention concerne également des procédés de synthèse pour l'obtention desdits composés.

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