C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/33 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2682981
Compounds of Formula I: in which A, B, R1, R1a, R2, R3, R4, R5 R6, R7 and R8 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. Particular compounds of this invention have also been found to be inhibitors of Pim-1.
Cette invention a trait à des composés de formule I dans laquelle A, B, R1, R1a, R2, R3, R4, R5 R6, R7 et R8 ont la signification énoncée dans la description, lesdits composés étant des inhibiteurs des récepteurs à activité tyrosine kinase utilisés dans le traitement des maladies associées aux récepteurs à activité tyrosine kinase de classe 3 et de classe 5. Des composés particuliers de l'invention se sont également avérés inhibiteurs de Pim-1.
Allen Shelley
Greschuk Julie Marie
Kallan Nicholas C.
Lyssikatos Joseph P.
Marmsater Fredrik P.
Array Biopharma Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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