C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4709 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2682231
Compounds of Formula (I): are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class (3) and class (5) receptor tyrosine kinases. Particular compounds of this invention have also been found to be inhibitors of Pim-1.
La présente invention concerne des composés de formule (I) dans laquelle A, B, R1, R1a, R2, R3, R4, R5, R6, R7 et R8 ont les significations proposées dans la spécification, sont des inhibiteurs de la tyrosine récepteur utiles dans le traitement de maladies médiées par les tyrosine kinases récepteurs de classe 3 et de classe 5. Des composés particuliers de cette invention se sont également avérés être des inhibiteurs de Pim-1.
Lyssikatos Joseph P.
Marmsaeter Fredrik P.
Munson Mark C.
Rizzi James P.
Robinson John E.
Array Biopharma Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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