Imidazo[1,2-a]pyridine derivatives

Details Imidazo[1,2-a]pyridine derivatives Imidazo[1,2-a]pyridine derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/435 (2006.01)

Patent

CA 2216809

The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0 represents halogen; R1 and R2 are independently selected from H, halogen, C1-4alkyl, C1-4alkyl substituted by one or more fluorine atoms, C1-4alkoxy, C1-4hydroxyalkyl, SC1-4alkyl, C(O)H or C(O)C1-4alkyl; and R3 represents C1-4alkyl. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of the pain, fever, inflammation of a variety of conditions and diseases.

L'invention décrit des composés de formule (I) et leurs sels pharmaceutiquement acceptables dans laquelle R?0¿ représente halogène; R?1¿ et R?2¿ sont choisis indépendamment parmi H, halogène, C¿1-4?alkyle, C¿1-4?alkyle substitué par un ou plusieurs atomes de fluor, C¿1-4?alkoxy, C¿1-4?hydroxyalkyle, SC¿1-4?alkyle, C(O)H ou C(O)C¿1-4?alkyle; et R?3¿ représente C¿1-4?alkyle. Les composés de formule (I) sont des inhibiteurs puissants et sélectifs de COX-2 et sont utilisés dans le traitement de la douleur, de la fièvre et de l'inflammation dans une variété d'états pathologiques et de maladies.

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