Imidazo[1,2-a]pyridine derivatives and their use as positive...

Details Imidazo[1,2-a]pyridine derivatives and their use as positive... Imidazo[1,2-a]pyridine derivatives and their use as positive...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2704436

The present invention relates to novel compounds, in particular novel imidazo[1,2- a]piridine derivatives according to Formula (I). The compounds according to the invention are positive allosteric modulators of metabotropic receptors- subtype type 2 ('mGluR2') which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved.

La présente invention concerne de nouveaux composés, en particulier de nouveaux dérivés imidazo[1,2-a]pyridine selon la formule (I), où tous les radicaux sont tels que définis dans la demande et les revendications. Les composés selon l'invention sont des modulateurs allostériques positifs des récepteurs métabotropiques de sous-type 2 (« mGluR2 ») qui sont utiles pour le traitement ou la prévention de troubles neurologiques et psychiatriques associés à un dysfonctionnement dû au glutamate et de maladies dans lesquelles le sous-type mGluR2 des récepteurs métabotropiques est impliqué. En particulier, de telles maladies sont des troubles du système nerveux central choisis dans le groupe comprenant l'anxiété, la schizophrénie, la migraine, la dépression, et l'épilepsie. L'invention concerne également des compositions pharmaceutiques et des procédés de préparation de tels composés et compositions, ainsi que l'utilisation de tels composés pour la prévention et le traitement des maladies dans lesquelles le mGluR2 est impliqué.

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