Imidazo[1,2-a]pyridine derivatives: preparation and...

Details Imidazo[1,2-a]pyridine derivatives: preparation and... Imidazo[1,2-a]pyridine derivatives: preparation and...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2602328

The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).

La présente invention porte sur des composés d'hydroxamate inhibiteurs de l'histone désacétylase. Ladite invention concerne plus particulièrement des composés contenant de l'imidazo[1,2-a]pyridine et leurs procédés de préparation. Ces composés peuvent être utiles en tant que médicaments pour le traitement de troubles prolifératifs et d'autres pathologies impliquant, liées à, ou associées à des enzymes présentant une activité histone désacétylase (HDAC).

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