C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/271, 260/246
C07D 471/04 (2006.01)
Patent
CA 1157470
ABSTRACT Imidazo[1/2-a]pyridines of the formula: Image and their acid addition salts in which Y represents a hydrogen or halogen atom or a C1-4 alkyl radical Z represents a naphthyl radical or a radical Image ,in which each of X1 and X2 independently of one another is a hydrogen or halogen atom, a C1-4 alkoxy radical, a C1-6 alkyl radical or CF3, CH3S-, CH3SO2- or -NO2, and each of R1 and R2 independently of one another represents a hydrogen atom, a straight or branched C1-5 alkyl radical which is unsubstituted or substituted by one or more halo- gen atom, hydroxyl, -N(C1-4 alkyl)2, carbamoyl or C1-4 alkoxy radicals, an allyl radlcal, a propargyl radical, a C3-6 cycloalkyl radical, the benzyl radical, or the phenyl radical, not both R1 and R2 being being hydrogen, or -NR1R2 represents a heterocyclic ring containing from 3 to 6 carbon atoms, or a heterocyclic ring of the formula Image , in which X is 0, S, CHOR' or Image , R' being hydrogen or benzyl and R being hydrogen, a C1-4 alkyl radical, or phenyl which is unsubstituted or substituted by methoxy or a halogen atom, which may be made for the corresponding acids, have valuable pharmacological properties, especially anxiolytic, anti-anoxic, sleep-inducing, hypnotic, and anticonvulsant properties.
388385
George Pascal
Kaplan Jean P.
Kirby Eades Gale Baker
Synthelabo
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