Imidazo [1,2-a] pyridines as jnk modulators

Details Imidazo [1,2-a] pyridines as jnk modulators Imidazo [1,2-a] pyridines as jnk modulators

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2749236

Compounds of formula (I) modulate JNK wherein X1 and X2 are each simultaneously N or CH; X3 is CH-R2 Or N-SO2R, where R is lower alkyl; R1 is aryl or heteroaryl, substituted with 0-3 lower alkyl radicals; R2 is (II), where R3 is H, lower acyl, or an amino acid, or a pharmaceutically acceptable salt thereof.

La présente invention concerne des composés de formule (I) modulant la JNK dans laquelle X1 et X2 représentent chacun simultanément N ou CH ; X3 représente CH-R2 ou N-SO2R, où R représente un alkyle de faible poids moléculaire ; R1 représente un aryle ou un hétéroaryle, substitué par 0 à 3 radicaux alkyle de faible poids moléculaire ; R2 représente (II), dans laquelle R3 représente H, un acyle de faible poids moléculaire, ou un acide aminé, ou un sel pharmaceutiquement acceptable de celui-ci.

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