C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/428 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01) A61P 3/00 (2006.01) A61P 7/02 (2006.01) A61P 17/06 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 233/84 (2006.01) C07D 239/22 (2006.01) C07D 277/82 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2730964
The invention relates to the novel products of formula (I): in which: n = 0,1 or 2; X is H, Hal or alk; R is H, NH2, NHalk or N(alk)2; Ra is H, Hal, -O-cycloalkyl, -O-alkyl, -O-aryl, -O-heteroaryl, -NRd(cycloalkyl), -NRd(alkyl), -NRd(aryl), -NRd(heteroaryl), alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, all optionally substituted; Rb is H, Rc, -COORc-CO-Rc or -CO-NRcRd; where Rc is alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, all optionally substituted; Rd is H, alk or cycloalkyl; these products being in all the isomer forms and the salts, as medicaments, in particular as MET inhibitors.
L'invention concerne les nouveaux produits de formule (I): dans laquelle : n = 0,1 ou 2; X représente H, HaI ou alk; R représente H, NH2, NHaIk, N(alk)2; Ra représente H; HaI; -O-cycloalkyle; -O- alkyle, -O-aryle; -O-hétéroaryle; - NRd(cycloalkyle); -NRd(alkyle); -NRd(aryle); -NRd(hétéroaryle); alkyle; cycloalkyle; hétérocycloalkyle; aryle ou hétéroaryle; tous éventuellement substitués; Rb représente H, Rc, -COORc-CO-Rc ou -CO- NRcRd; avec Re représente alkyle, cycloalkyle, hétérocycloalkyle, aryle et hétéroaryle, tous éventuellement substitués; Rd représente H, alk ou cycloalkyle; ces produits étant sous toutes les formes isomères et les sels, à titre de médicaments notamment comme inhibiteurs de MET.
Bacque Eric
Damour Dominique
Nemecek Conception
Nemecek Patrick
Schio Laurent
Robic
Sanofi-Aventis
LandOfFree
Imidazo [1, 2-a] pyrimidine derivatives method for the... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Imidazo [1, 2-a] pyrimidine derivatives method for the..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazo [1, 2-a] pyrimidine derivatives method for the... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1483839