Imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepine...

Details Imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepine... Imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepine...

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/55 (2006.01) C07D 491/14 (2006.01) C07D 491/147 (2006.01) C07D 495/14 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2102889

The present invention is concerned with novel imidazo[1,2-a](pyrrolo, thieno or furano)[3,2-d]azepines of formula (I), the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines inde- pendently represents an optional bond; R1 represents hydrogen, C1-4alkyl, halo, ethenyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, hydroxyC1-4alkyl, formyl, hydroxycarbonyl or hydroxycarbonylC1-4alkyl; R2 represents hydrogen, C1-4alkyl, ethenyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, C1-4alkyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, hydroxyC1-4alkyl, formyl or hydroxycarbonyl; R3 represents hydrogen, C1-4alkyl, hydroxyC1-4alkyl, phenyl or halo; L represents hydrogen; C1-6alkyl; C1-6alkyl substituted with one substituent selected from the group consist- ing of hydroxy, halo, C1-4alkyloxy, hydroxycarbonyl, C1-4alkyloxycarbonyl, C1- 4alkyloxycarbonylC1-4alkyloxy, hydroxy- carbonylC1-4alkyloxy, C1-4alkyloxycarbonylamino, C1-4alkylaminocarbonyl, C1- 4alkylaminocarbonylamino, C1-4alkylamin- othiocarbonylamino, aryl, aryloxy and arylcarbonyl; C1-6alkyl substituted with both hydroxy and aryloxy; C3-6alkenyl; C3- 6alkenyl substituted with aryl; L represents a radical of formula -Alk-Y-Het1 (a-1), -Alk-NH-CO-Het2 (a-2) or Alk-Het3 (a-3; which are useful antiallergic compounds. Compositions comprising said compounds, methods of using, and processes for preparing the same.

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