Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine...

Details Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine... Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2667487

The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II), or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.

L'invention concerne des inhibiteurs de protéines kinases qui comprennent des composés d'imidazo[1,2-b]pyridazine et de pyrazolo[1,5-a]pyrimidine représentés par les structures (I) et (II) suivantes, ou un stéréo-isomère, un promédicament ou un sel pharmaceutiquement acceptable de ceux-ci. Dans la formule, R, R1, R2 et X sont tels que définis dans la demande. L'invention concerne aussi des compositions et des procédés d'utilisation de celles-ci dans le traitement du cancer et d'autres états pathologiques associés à une kinase Pim.

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