Imidazo [1, 2-b] pyridazines, their processes of preparation...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/5025 (2006.01) A61P 25/08 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01)

Patent

CA 2647116

The invention provides novel imidazo[1,2-b]pyridazines of formula (I) and pharmaceutically acceptable salts, polymorphs, hydrates, tautomers, solvates and stereoisomers thereof. Compounds of formula (I) are useful for treating or preventing diseases associated with GABAA receptors modulation, anxiety, epilepsy, sleep disorders including insomnia, and for inducing sedation-hypnosis, anesthesia, sleep and muscle relaxation. The invention also provides synthetic procedures for preparing said compounds and certain intermediates, as well as intermediates themselves.

L'invention concerne de nouveaux imidazo[1,2-b]pyridazines de formule (I) et des sels acceptables pharmaceutiquement, des polymorphes, des hydrates, des tautomères, des solvates et des stéréoisomères associés. Des composés de la formule (I) sont utilisés pour traiter ou prévenir des maladies liées à la modulation des récepteurs GABAA, l'anxiété, l'épilepsie, les troubles du sommeil notamment l'insomnie et pour induire une hypnose couplée à la sédation, une anesthésie, le sommeil et une relaxation musculaire. Cette invention a aussi pour objet des procédés synthétiques servant à préparer lesdits composés et certains intermédiaires, ainsi que ces mêmes intermédiaires.

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