Imidazo [2,1-b] [1,3,4] thiadiazole derivatives

C - Chemistry – Metallurgy – 07 – D

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Details

C07D 513/04 (2006.01) A61K 31/41 (2006.01) A61K 35/00 (2006.01) A61P 17/06 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 31/12 (2006.01) A61P 33/00 (2006.01)

Patent

CA 2756873

There is provided compounds of formula (I): wherein R1, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. P13-K, particularly class I P13K) is desired and/or required, and particularly in the treatment of cancer.

La présente invention concerne des composés de formule (I) : dans laquelle R1, R2 et R3 ont les significations données dans la description, et les esters, amides, solvates ou sels pharmaceutiquement acceptables de ceux-ci. Lesdits composés sont utiles pour le traitement de maladies dans lesquelles l'inhibition d'une protéine ou lipide kinase (par exemple les PI-3K, en particulier les PI3K de classe I) est souhaitée et/ou requise, et en particulier pour le traitement du cancer.

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