C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/55 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2103242
The present invention is concerned with novel imidazo[2,1-b][3]benzazepines of formula (I), the pharmaceutically accept- able addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an op- tional bond; R1 represents hydrogen, halo, C1-4alkyl or C1-4alkyloxy; R2 represents hydrogen, halo, C1-4alkyl or C1-4alky- loxy; R3 represents hydrogen, C1-4alkyl, ethenyl substituted with hydroxycarbonyl or C1-4alkyloxycarbonyl, C1-4alkyl substi- tuted with hydroxycarbonyl or C1-4alkyloxycarbonyl, hydroxyC1-4alkyl, formyl or hydroxycarbonyl; R4 represents hydrog- en, C1-4alkyl, hydroxyC1-4alkyl, phenyl or halo; R5 represents hydrogen, C1- 4alkyl or halo; L represents hydrogen; C1-6al- kyl; C1-6alkyl substituted with one substituent selected from the group consisting of hydroxy, halo, C1-4alkyloxy, hydroxy- carbonyl, C1-4alkyloxycarbonyl, C1-4alkyloxycarbonyl-C1-4alkyloxy, hydroxycarbonylC1-4alkyloxy, C1-4alkyloxycarbony- lamino, C1-4alkylaminocarbonyl, C1-4alkylaminocarbonylamino, C1- 4alkylaminothiocarbonylamino, aryl, aryloxy and aryl- carbonyl; C1-6alkyl substituted with both hydroxy and aryloxy; C3-6alkenyl; C3- 6alkenyl substituted with aryl; or, L repres- ents a radical of formula -Alk-Y-Het1 (a-1), -Alk-NH-CO-Het2 (a-2) or -Alk- Het3 (a-3); provided that 6,11-dihydro- 11-(4-piperidinylidene)-5H-imidazo[2,1-b][3]benzazepine is excluded, which are useful antiallergic compounds. Compositions comprising said compounds, methods of using and processes for preparing the same.
Diels Gaston S. M.
Janssens Frans E.
Leenaerts Joseph E.
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica Naamloze Vennootschap
Janssen Pharmaceutica N.v.
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