Imidazo- and pyrrolo[1,2-a]pyrimid-4-ones as...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61P 15/00 (2006.01) C07D 209/00 (2006.01) C07D 235/00 (2006.01) C07D 239/00 (2006.01)

Patent

CA 2372044

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have structure (I) including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein Ar, B, R1, R2, R3a, R3b, R4, R5, R6 and m are as defined herein.

La présente invention concerne des antagonistes du récepteur de GnRH utilisés dans le traitement d'états variés liés aux hormones sexuelles à la fois chez l'homme et la femme. Ces composés sont représentés par la formule (1), y compris les stéréoisomères, les promédicaments et les sels de ceux-ci acceptables sur le plan pharmaceutique, dans laquelle Ar, B, R¿1?, R¿2?, R¿3a?, R¿3b?, R¿4?, R¿5?, R¿6? et m sont tels que définis ci-dessus.

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