C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61P 3/00 (2006.01)
Patent
CA 2611529
Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure:(I) or stereoisomers or pharmaceutically acceptable salts thereof, wherein W, L, R3, R3a, R3b and R4 are defined herein.
L'invention concerne de nouveaux composés qui constituent des inhibiteurs de type I de 11-.beta.-hydroxystéroïde déshydrogénase. Des inhibiteurs de type I de 11-.beta.-hydroxystéroïde déshydrogénase sont utilisés dans le traitement, la prévention ou le ralentissement de la progression de maladies nécessitant une thérapie impliquant des inhibiteurs de type I de 11-.beta.-hydroxystéroïde déshydrogénase. Ces nouveaux composés possèdent la structure (I) ou des stéréoisomères ou des sels acceptables pharmaceutiquement, W, L, R3, R3a, R3b et R4 étant définis dans la description.
Cooper Christopher B.
Hamann Lawrence G.
Li James J.
Li Jun
Robl Jeffrey A.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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