Imidazo benzodiazepine derivatives

Details Imidazo benzodiazepine derivatives Imidazo benzodiazepine derivatives

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/55 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2625611

The present invention is concerned with substituted imidazo[1,5- a][1,2,4]triazolo[1,5- d][1,4]benzodiazepine derivatives of the following formula (I) wherein the definition of substituents is described in the claims. It has been found that this class of compounds show high affinity and selectivity for GABA .alpha.5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.

La présente invention a trait à des dérivés substitués d'imidazo[1,5-a][1,2,4]triazolo[1,5- d][1,4]benzodiazépine de formule (I), dans laquelle les substituants sont tels que définis dans les revendications. On a observé que cette classe de composés présentent une affinité et une sélectivité élevées pour des sites de liaison au récepteur GABA a5 et peuvent être utiles en tant que activateur cognitif ou pour le traitement de troubles cognitifs tels que la maladie d'Alzheimer.

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