Imidazo-benzodiazepines and their use in the treatment of...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/55 (2006.01)

Patent

CA 1310638

ABSTRACT OF THE DISCLOSURE: Disclosed are compounds of formula (I): Image (I) wherein R1 represents a phenyl group, a C4-C6 cycloalkyl group or a group of formula (II): Image (II) (in which R4 represents hydrogen or C1-C5 alkyl: R5 represents hydrogen or C1-C5 alkyl; and R6 represents hydrogen, C1-C5 alkyl, phenyl, halogen, C2-C5 alkoxycarbonyl, cyano, amido or C1-C5 mono- or dialkylamido), R2 and R3, which may be identical or different, each represents a hydrogen atom, a C1-C5 alkyl group or a C2-C5 cycloalkyl group, or R2 and R3 together represent a C3-C5 alkylene group; and X and Y, which may be identical or different, each represents a hydrogen atom, a halogen atom, a nitro,azido, nitrile or trifluoromethyl group or an alkyl or alkoxy group containing 1 to 3 carbon atoms. These compounds and their acid addition salts are useful as medicaments, particularly in the treatment of memory disorders or cerebral senescence disorders. Some compounds may also be used in the treatment of obesity and as minor tranquillisers in the treatment of certain agitated or irritated conditions, and certain forms of epilepsy.

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