Imidazo-isoquinoline compounds, their compositions and uses

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/437 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01)

Patent

CA 2346414

The subject invention involves compounds having structure (<u>1</u>) wherein the C.alpha.-N.beta. and C5-C6 bonds are independently single or double bonds, R1 is selected from alkyl, aryl, and heterocycle; R2 - R13 are independently selected from hydrogen and other substituents; and pharmaceutically-acceptable salts thereof. The ubject invention also involves pharmaceutical compositions containing such compounds, and methods for treating or preventing diseases and disorders using such compounds.

L'invention porte sur des composés de structure: (<u>1</u>) dans laquelle les liaisons C.alpha.-N.beta., et C¿5?-C¿6? sont indépendamment simples ou doubles; R1 est choisi parmi alkyle, aryle, et un hétérocycle; R2 R13 sont choisis indépendamment parmi hydrogène et d'autres substituants; et sur leurs sels pharmacocompatibles. L'invention porte également sur des compositions pharmaceutiques contenant lesdits composés et sur des procédés de traitement et de prévention de maladies et de troubles utilisant lesdits composés.

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