Imidazo-pyridine derivatives as activin-like receptor kinase...

Details Imidazo-pyridine derivatives as activin-like receptor kinase... Imidazo-pyridine derivatives as activin-like receptor kinase...

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/437 (2006.01) C07D 405/10 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2722131

Compounds of formula (I): in free or salt or solvate form, where X, R1, R2, R3 and R4 have the meanings as indicat-ed in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical composi-tions that contain the compounds and processes for preparing the compounds are also described.

La présente invention concerne des composés de formule (I) sous forme libre ou sous forme de sel ou de solvate. Dans la formule (I), X, R1, R2, R3 et R4 ont les significations énoncées dans la description. Ces composés sont utilisés pour traiter des maladies à médiation par le récepteur ALK-5 et/ou ALK-4. L'invention concerne également des compositions pharmaceutiques qui contiennent lesdits composés et des procédés de préparation de ces composés.

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