C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 25/00 (2006.01) C07D 221/00 (2006.01) C07D 235/00 (2006.01)
Patent
CA 2384048
A class of 3-phenylimidazo[4,5-b]pyridine derivatives, substituted at the meta position of the phenyl ring by a range of substituents, are selective ligands for GABAA receptors, in particular having high affinity for the .alpha.2 and/or .alpha.3 subunit thereof, and are accordingly of benefit in the treatment and/or prevention of disorders of the central nervous system, including anxiety and convulsions.
La présente invention concerne une classe de dérivés de 3-phenylimidazo[4,5-b]pyridine, substitués à la méta position du cycle phénylique par une gamme de substituants. Ces dérivés sont des ligands sélectifs destinés aux récepteurs GABAa, qui ont en particulier une grandes affinité pour leurs sous unités .alpha.2 et/ou .alpha.3 et qui, de ce fait conviennent pour le traitement et/ou la prévention de troubles du système nerveux central, notamment l'anxiété et les convulsions.
Hallett David James
Rowley Michael
Merck Sharp & Dohme Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
LandOfFree
Imidazo-pyridine derivatives as ligands for gaba receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Imidazo-pyridine derivatives as ligands for gaba receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazo-pyridine derivatives as ligands for gaba receptors will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1956158