Imidazo-thiazole derivatives as protein kinase inhibitors

Details Imidazo-thiazole derivatives as protein kinase inhibitors Imidazo-thiazole derivatives as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/425 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2705906

Compounds of formula I that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula I and therapeutically acceptable salts, prodrugs and salts of prodrugs thereof, wherein X is CH or N; A1 is R1, OR NHR1, N1(R1)2, NHC(O)R1, NHC(O)NHR1, NHC(O)N(R1)2, NHC(O)OR C(O)NHR, C(O)N(R1)2, C=NOR , or C(NH2)NOC(O)R1;

La présente invention concerne des composés de formule I et leurs sels, promédicaments et sels de promédicaments , dans laquelle : X est CH ou N; A1 est R1, OR1. NHR1, N(R1)2, NHC(O)R1, NHC(O)NHR1, NHC(O)N(R1)2, NHC(O)OR1, C(O)NHR1, C(O)N(R1)2, C=NOR1, ou C(NH2)NOC(O)R1. Les composés selon l'invention sont inhibiteurs des protéines kinases. L'invention concerne également des compositions contenant les composés et des procédés de traitement de maladies mettant en uvre les composés.

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