Imidazo-triazine derivatives as ligands for gaba receptors

Details Imidazo-triazine derivatives as ligands for gaba receptors Imidazo-triazine derivatives as ligands for gaba receptors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/53 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2451445

A class of 7-phenylimidazo[1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by a (cyano)(fluoro)phenyl moiety, being selective ligands for GABAA receptors, in particular having good affinity for the .alpha.2 and/or .alpha.3 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety and convulsions.

L'invention porte sur une classe de dérivés de 7-phénylimidazo[1,2-<i>b</i>][1,2,4]triazine, substitués à la position <i>meta</i> du noyau phényle par une fraction (cyano)(fluoro)phényle, ces dérivés étant des ligands sélectifs pour les récepteurs GABA¿A?, et ayant notamment une bonne affinité pour la sous-unité .alpha.2 et/ou .alpha.3 de ceux-ci. Le dérivés de cette invention sont avantageux dans le traitement et/ou la prévention d'états secondaires du système nerveux central tels que l'anxiété et les convulsions.

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