Imidazo-triazine derivatives as ligands for gaba receptors

Details Imidazo-triazine derivatives as ligands for gaba receptors Imidazo-triazine derivatives as ligands for gaba receptors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/53 (2006.01) A61P 25/00 (2006.01) C07D 235/00 (2006.01) C07D 253/00 (2006.01)

Patent

CA 2427779

A class of 7-phenylimidazo [1,2-b][1,2,4]triazine derivatives, substituted at the meta position of the phenyl ring by an optionally substituted aryl or heteroaryl group which is directly attached or bridged by an oxygen atom or a - NH- linkage, being selective ligands for GABAA receptors, in particular having good affinity for the .alpha.2 and/or .alpha.3 and/or .alpha.5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

L'invention concerne une classe de dérivés de 7-phénylimidazo [1,2-b][1,2,4]triazine, substitués en position meta du noyau phényle par un groupe aryle ou hétéroaryle éventuellement substitué, qui est directement lié ou ponté par un atome d'oxygène ou une liaison -NH-. Ces dérivés, qui constituent des ligands sélectifs de récepteurs GABA¿A? et possèdent en particulier une bonne affinité à l'égard de la sous-unité .alpha.2 et/ou .alpha.3 et/ou .alpha.5 de ceux-ci, sont par conséquent utiles dans le traitement et/ou la prévention d'états pathologiques du système nerveux central, y compris l'anxiété, les convulsions les troubles cognitifs.

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