Imidazobenzodiazepines

Details Imidazobenzodiazepines Imidazobenzodiazepines

C - Chemistry, Metallurgy

07

D

260/239.4

C07D 487/04 (2006.01) C07D 233/54 (2006.01) C07D 295/205 (2006.01) C07D 403/12 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1180011

- 1 - 4-13694/CGC 961/+ Imidazobenzodiazepines Abstract of the disclosure The invention concerns psychoactive and antihistaminic compounds of the formula I (I) Image wherein each of the symbols Rl and R2 is hydrogen, lower alkyl, lower alkanoyl, halogen, cyano, carboxy, lower alkoxycarbonyl, carbamoyl, sulfamoyl, mono- or di-lower alkyl-(carbamoyl or sulfamoyl); CnH2n is lower alkylene separating both nitrogen atoms by 2 or 3 carbon atoms; R3 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, lower alkanoyl, aryl lower alkyl, lower alkoxycarbonyl, phenyl lower alkoxycarbonyl or (hydroxy, lower alkanoyloxy, aryloxy or lower alkoxy) lower alkyl having at least two carbon atoms; R4 and R5 in- dependently represent hydrogen, lower alkyl, lower alkoxy, lower alkylthio, halogen, trifluoromethyl, hydroxy, lower alkanoyloxy, sulfamoyl, mono- or di-lower alkylsulfamoyl; and R6 and R7 represent hydrogen or lower alkyl; the N-oxides, lower alkyl quaternary derivatives, and salts. They are prepared, for example, by condensing a compound of formula III

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