C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/238.5
C07D 513/04 (2006.01) C07D 233/84 (2006.01)
Patent
CA 1163630
4-12896/CGC 921/+ Imidazobenzothiadiazepines, process for their manufacture, pharmaceu- tical preparations containing these compounds and their therapeutic application Abstract of the disclosure The invention concerns the compounds of the Formula I Image (I) wherein each of R1 and R2 is hydrogen, lower alkyl, lower alkanoyl, halogeno, cyano, carboxy, lower carbalkoxy, carbamoyl, sulfamoyl, mono- or di-lower alkyl-(carbamoyl or sulfamoyl); Ph is 1,2- phenylene, unsubstituted or substituted by up to two identical or different members selectet from lower alkyl, lower alkoxy, lower alkylthio, halogeno, trifluoromethyl, sulfamoyl, mono- or di-lower alkylsulfamoyl; each of CmH2m ant CnH2n is lower alkylene separating both nitrogen atoms by 2 or 3 carbon atoms, and R3 is hydrogen, lower alkyl, lower alkanoyl, lower alkoxycarbonyl, phenyl-lower alkoxy- carbonyl or hydroxy-lower alkyl, wherein the hydroxy group is separated from the nitrogen atom by at least 2 carbon atoms; their N- and/or S-oxides, and lower alkyl quaternary derivatives thereof salts of all these compounds. The compounds exhibit neuroleptic activity. They are prepared by concensing a compound of the general Formula III or a salt thereof with a compound of the general Formula IV - 1 - Image (III) (IV) wherein X is halogeno, lower alkoxy, lower alkylthio, cyanato or thio- cyanato; Y is hydrogen or an alkali metal; p is an integer from 0 to 2, and the remaining symbols have the meaning given for formula I. - 2 -
379490
Fetherstonhaugh & Co.
Novartis Ag
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