Imidazodiazepine

Details Imidazodiazepine Imidazodiazepine

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/55 (2006.01) C07D 487/04 (2006.01) C07D 495/14 (2006.01) C07D 495/22 (2006.01)

Patent

CA 2069382

RAN 4008/351 Abstract The novel imidazodiazepine derivatives of the general formula Image I wherein A and the two carbon atoms denoted by .alpha. and .beta. together signify one of the groups Image , Image , Image , (a) (b) (c) B signifies one of the residues Image , Image , Image (d) (e) (f) Q signifies one of the groups Image , Image (g) (h) R1 signifies a lower alkyl group, which is optionally substituted by C3-C6-cycloalkyl, hydroxy, lower alkoxy, aryl, aroyl, aryloxy, heteroaroyloxy, acyloxy, aryl-(lower)-alkoxy, halogen, the group -NR4R5 or a five-membered heterocycle bonded via a carbon atom or a nitrogen atom, a lower alkenyl or alkynyl group, an aroyl group, a five-membered heterocycle bonded via a carbon atom or C3 6-cycloalkyl optionally substituted by acyl or lower alkyl, R2 and R3 each signify hydrogen, halogen or lower alkyl, R4 signifies hydrogen or lower alkyl, R5 signifies hydrogen, aryl, acyl, C3-6-cycloalkyl, aralkyloxy- carbonyl or lower alkyl which is optionally substituted by aryl, morpholino, lower alkoxy, hydroxy, 2,2-dimethyl- 1,3 - dioxolan-4-yl, alkoxycarbonyl, carbamoyl, alkoxycarbonyl- amino, aralkoxycarbonyl or amino or R4 and R5 together with the nitrogen atom signify either phthalimino or a six- membered saturated heterocycle, can be used for the control or prevention of illnesses. They are especially suitable for the control or prevention of epileptic seizures, anxiety, tension and excitation states, sleep disorders, schizophrenic symptoms, hepatic encephalopathy and senile dementiae as well as in the partial or antagonization of undesired side-effects of substances acting on benzodiazepine receptors after over-dosage or after their use in intensive medicine and in anaesthesia.

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