Imidazoindolizine derivatives and process for preparation...

Details Imidazoindolizine derivatives and process for preparation... Imidazoindolizine derivatives and process for preparation...

C - Chemistry, Metallurgy

07

D

C07D 471/14 (2006.01) A61K 31/435 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2077420

- 56 - An imidazoindolizine derivative of the formula [I]: Image wherein R1 is lower alkyl, R2 is hydrogen, cyano, lower alkyl, lower alkanoyl, lower alkoxycarbonyl, phenyl-lower alkoxycarbonyl, lower alkylsulfonyl, substituted or unsubstituted phenyl, arylcarbonyl, or 5- or 6-membered nitrogen-containing heteromonocyclic group-substituted carbonyl, Ring A is substituted or unsubstituted phenyl, and m is 0 or 1, or a pharmaceutically acceptable salt thereof, and process for preparation thereof, said imidazoindolizine derivatives and pharmaceutically acceptable salts thereof show excellent angiotensin II inhibitory activities and are useful in the prophylaxis or treatment of hypertension.

Dérivé d'imidazopyridine de formule (I) Image , dans laquelle R1 est un alkyle inf., R2 est de l'hydrogène, un groupe cyano, alkyle inf., alcanoyle inf., alcoxy(inf.)carbonyle, phénylalcoxy(inf.)carbonyle, alkyl(inf.)sulfonyle, phényle avec ou sans substitution, arylcarbonyle ou carbonyle avec substitution par un groupe hétéromonocyclique azoté à 5 ou 6 chaînons, le cycle A est un phényle avec ou sans substitution, et m est 0 ou 1; ou un sel de ce dérivé, acceptable en pharmacie; méthodes pour préparer ces composés. Lesdits dérivés d'imidazopyridine et leurs sels de qualité pharmaceutique, sont d'efficaces inhibiteurs de l'angiotensine II et sont utiles pour la prévention ou le traitement de l'hypertension.

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