Imidazol-2-yl derivatives of substituted bicyclic compounds...

Details Imidazol-2-yl derivatives of substituted bicyclic compounds... Imidazol-2-yl derivatives of substituted bicyclic compounds...

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2074729

2074729 9209582 PCTABS00013 Compounds having formula (I) wherein Z is -O- or -CH2-; n is 1-6; R is hydrogen, C1-C6 alkyl, phenyl or optionally substituted phenyl-C1-C3 alkyl; R2 is C1-C8-alkyl, aryl-C1-C3 alkyl, C5-C8 cycloalkyl or C5-C8 cycloalkyl-C1-C3 alkyl; each of R3 and R4 independently is hydrogen or C1-C4 alkyl, or taken together with the carbon atom to which they are linked form a C3-C6 cycloalkyl ring; Q is -OR' or -NR'R" in which R' and R" are as herein defined, or Q is C1-C8 alkyl, phenyl, phenyl-C1-C3-alkyl, C5-C8 cycloalkyl or C5-C8 cycloalkyl-C1-C3 alkyl, in which both the phenyl and cycloalkyl rings or moieties are optionally substituted as herein defined; and the pharmaceutically acceptable salts thereof; are useful in particular as antidislipidaemic and antiatherosclerotic agents.

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