A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4709 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2290992
The invention comprises the use of compounds of formula (I) wherein the dotted line represents an optional bond; X is oxygen or sulfur; R1 is hydrogen, C1-12alkyl, Ar1, Ar2C1-6alkyl, quinolinylC1-6alkyl, pyridylC1-6alkyl, hydroxyC1-6alkyl, C1-6alkyloxyC1-6alkyl, mono- or di(C1-6alkyl)aminoC1-6alkyl, aminoC1-6alkyl, or a radical of formula -Alk1-C(=O)-R9, -Alk1-S(O)-R9 or -Alk1-S(O)2-R9; R2, R3 and R16 each independently are hydrogen, hydroxy, halo, cyano, C1-6alkyl, C1-6alkyloxy, hydroxyC1-6alkyloxy, C1-6alkyloxyC1-6alkyloxy, aminoC1-6alkyloxy, mono- or di(C1-6alkyl)aminoC1-6alkyloxy, Ar1, Ar2C1-6alkyl, Ar2oxy, Ar2C1-6alkyloxy, hydroxycarbonyl, C1-6alkyloxycarbonyl, trihalomethyl, trihalomethoxy, C2-6alkenyl; R4 and R5 each independently are hydrogen, halo, Ar1, C1-6alkyl, hydroxyC1-6alkyl, C1-6alkyloxyC1-6alkyl, C1-6alkyoloxy, C1-6alkylthio, amino, hydroxycarbonyl, C1-6alkyloxycarbonyl, C1-6alkylS(O)C1-4alkyl or C1-6alkylS(O)2C1-6alkyl; R6 and R7 each independently are hydrogen, halo, cyano, C1-6alkyl, 4,4-dimethyl-oxazolyl, C1-6alkyloxy or Ar2oxy; R8 is hydrogen, C1- 6alkyl, cyano, hydroxycarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonylC1-6alkyl, cyanoC1-6alkyl, C1-6alkyloxycarbonylC1-6alkyl, carboxyC1-6alkyl, hydroxyC1-6alkyl, aminoC1-6alkyl, mono-- or di(C1-6alkyl)aminoC1-6alkyl, imidazolyl, haloC1-6alkyl, C1- 6alkyloxyC1-6alkyl, aminocarbonylC1-6alkyl, or a radical of formula -O-R10, -S-R10, -N-R11O12; R17 is hydrogen, halo, cyano, C1-6alkyl, C1- 6alkyloxycarbonyl, Ar1; R18 is hydrogen, C1-6alkyl, C1-6alkyloxy or halo; R19 is hydrogen or C1-6alkyl; for the manufacture of a medicament to inhibit smooth muscle cell proliferation.
L'invention concerne des composés selon la formule (I) dans laquelle la ligne en pointillés représente une liaison éventuelle. X est de l'oxygène ou du soufre. R<1> est de l'hydrogène, alkyle C1-12, Ar<1>, Ar<2> C1-6alkyle, quinolinylC1-6alkyle, pyridylC1-6alkyle, hydroxyC1-6alkyle, C1-6alkyloxyC1-6alkyl, mono- ou di(C1-6alkyl)aminoC1-6alkyle, aminoC1-6alkyle, ou un radical de la formule -Alk<1>-C(=O)-R<9>, -Alk<1>-S(O)-R<9> ou -Alk<1>-S(O)2-R<9>; R<2>, R<3> et R<16> sont chacun, indépendamment, hydrogène, hydroxy, halo, cyano, C1-6alkyle, C1-6alkyloxy, hydroxy C1-6alkyloxy, C1-6alkyloxy C1-6alkyloxy, amino C1-6alkyloxy, mono- ou di(C1-6alkyl)amino C1-6alkyloxy, Ar<1>, Ar<2>C1-6alkyle, Ar<2>oxy, Ar<2>C1-6alkyloxy, hydroxycarbonyl, C1-6alkyloxycarbonyl, trihalométhyle, trihalométhoxy, C2-6alkényl, R<4> et R<5> sont chacun, indépendamment, hydrogène, halo Ar<1>, C1-6alkyle, hydroxy C1-6alkyle, C1-6alkyloxy C1-6alkyle, C1-6alkyloxy, C1-6alkylthio, amino, hydroxycarbonyl, C1-6alkyloxycarbonyl, C1-6alkylS(O) C1-6alkyle ou C1-6alkylS(O)2 C1-6alkyle; R<6> et R<7> sont chacun, indépendamment, hydrogène, halo, cyano, C1-6alkyle, 4,4-diméthyl-oxazolyl, C1-6alkyloxy ou Ar<2>oxy; R<8> est hydrogène, C1-6alkyle, cyano, hydroxycarbonyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonylC1-6alkyle, cyanoC1-6alkyle, C1-6alkyloxycarbonylC1-6alkyle, carboxyC1-6alkyle, hydroxyC1-6alkyle, aminoC1-6alkyle, mono- ou di(C1-6alkyl)aminoC1-6alkyle, imidazolyl, haloC1-6alkyle, C1-6alkyloxyC1-6alkyle, aminocarbonylC1-6alkyle, ou un radical de la formule -O-R<10>, -S-R<10>, -N-R<11>R<12>; R<17> est hydrogène, halo, cyano, C1-6alkyle, C1-6alkyloxycarbonyl, Ar<1>; R<18> est hydrogène, C1-6alkyle, C1-6alkyloxy ou halo; R<19> est hydrogène ou C1-6alkyle. Ces composés sont utiles dans la fabrication d'un médicament permettant d'inhiber la prolifération des cellules des muscles lisses.
End David William
Zelesko Michael J.
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
LandOfFree
(imidazol-5-yl)methyl-2-quinolinone derivatives as... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with (imidazol-5-yl)methyl-2-quinolinone derivatives as..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (imidazol-5-yl)methyl-2-quinolinone derivatives as... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1608074