Imidazole antiproliferative agents

Details Imidazole antiproliferative agents Imidazole antiproliferative agents

C - Chemistry, Metallurgy

07

D

C07D 233/54 (2006.01) A61K 31/4164 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2378942

Compounds of formula (I) or a pharmaceutically acceptable salt or prodrug thereof, wherein R1 is selected from the group consisting of hydrogen, methyl, ethyl, propyl, and isolpropyl; and one of R2 or R3 is 3,4,5-trimethoyxphenyl, and the other is phenyl substituted with one, two, or three substitutents independently selected from the group consisting of alkoxy, halo, and -NR4R5, wherein R4 and R5 are independently selected from the group consisting of hydrogen and alkyl, inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.

L'invention concerne des composés de formule (I) qui empêchent la prolifération des cellules, des procédés de préparation de ces composés, des compositions pharmaceutiques contenant ces composés et des traitements à base des composés susmentionnés.

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