Imidazole compounds and medicinal use thereof

Details Imidazole compounds and medicinal use thereof Imidazole compounds and medicinal use thereof

C - Chemistry, Metallurgy

07

D

C07D 233/54 (2006.01) A61K 31/4174 (2006.01) A61K 31/4178 (2006.01) A61P 3/10 (2006.01) A61P 43/00 (2006.01) C07D 233/64 (2006.01) C07D 233/68 (2006.01) C07D 233/90 (2006.01) C07D 233/94 (2006.01) C07D 401/06 (2006.01) C07D 405/10 (2006.01) C07D 409/10 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2356838

Imidazole compounds represented by general formula (I) and salts thereof and medicinal compositions containing the same. These compounds are useful in treating diseases which can be treated based on the hypoglycemic effect thereof, and diseases which can be treated based on the cGMP-PDE inhibitory effect, smooth muscular relaxant effect, bronchodilating effect, vasodilating effect, smooth muscle cell regulatory effect and allergy-inhibitory effects thereof, wherein each symbol is as defined in the description.

La présente invention concerne des composés d'imidazole représentés par la formule générale (I), certains de leurs sels et des compositions médicinales à base de ces composés et de leurs sels. Ces composés conviennent au traitement d'une part d'affections contre lesquelles on peut intervenir, grâce à l'effet hypoglycémiant de ces composés, et d'autre part d'affections contre lesquelles on peut intervenir grâce à l'effet inhibiteur des cGMP-PDE, à l'effet myorelaxant des muscles lisses, à l'effet vasodilatateur, à l'effet cellulaire régulateur des muscles lisses, et à l'effet inhibiteur des allergies de ces composés. Les différents symboles de la formule sont tels que décrits dans la description.

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