C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/88 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) A61K 31/454 (2006.01) A61K 31/496 (2006.01) A61K 31/5377 (2006.01) A61P 25/28 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2560580
The present invention relates to compounds of the Formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and A are as defined. Compounds of the Formula (I) have activity inhibiting production of A.beta.-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer~s disease, in a mammal comprising compounds of the Formula (I).
La présente invention concerne des composés de formule (I), dans laquelle R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7> et A sont tels que définis dans le mémorandum descriptif. Les composés de formule (I) présentent une activité qui inhibe la production de peptides AB. L'invention concerne également des compositions pharmaceutiques contenant les composés de formule (I), et des méthodes de traitement de maladies et de troubles, tels que des troubles neurodégénératifs et/ou neurologiques, notamment la maladie d'Alzheimer, chez un mammifère.
Brodney Michael Aaron
Coffman Karen Jean
Pfizer Products Inc.
Smart & Biggar
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