C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/54 (2006.01) A61K 31/4178 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/04 (2006.01) C07D 403/10 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 487/04 (2006.01) C07D 487/08 (2006.01)
Patent
CA 2619068
The present invention relates to compounds of Formula (I) wherein R1, R2, R3, R4, R6, R7 and A are as defined. Compounds of Formula (I) have activity inhibiting production of A.beta.-peptide. The invention also relates to pharmaceutical compositions and methods for treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of Formula (I).
La présente invention a trait à des composés de formule (I), dans laquelle R1, R2, R3, R4, R6, R7 et A sont tels que définis dans la description. Les composés de formule (I) présentent une activité inhibitrice de la production de peptide Aß. L'invention a également trait à des compositions pharmaceutiques et à des procédés pour le traitement de maladies et de troubles, par exemple, des troubles neurodégénératifs et/ou neurologiques, tels que la maladie d'Alzheimer, chez un mammifère comprenant des composés de formule (I).
Brodney Michael Aaron
Chen Yuhpyng Liang
Coffman Karen Jean
Kleinman Edward Fox
O'neill Brian Thomas
Pfizer Products Inc.
Torys Llp
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