Imidazole compounds, their preparation and use

Details Imidazole compounds, their preparation and use Imidazole compounds, their preparation and use

C - Chemistry, Metallurgy

07

D

C07D 235/06 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 405/10 (2006.01) C07D 409/10 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2092211

The present invention discloses compounds of the formula Image wherein X is C or N; Y is C or N; R11 is hydrogen, hydroxy, or alkoxy; R12 and R13 are each independently hydrogen; halogen; CF3; CN; OH; alkyl; cycloalkyl; cycloalkylalkyl; alkenyl; alkynyl; alkoxy; phenylalkyl; amino; nitro; sulphamoyl; pipiridyl; pyrrolldinyl; acyl; CO2H; CO2-alkyl; CO-amino; NH-CO- alkyl; phenylsulphonyl which may be substituted with halogen; CF3, CN, OH, alkyl, alkenyl, alkynyl, alkoxy, amino, or nitro; phenyloxy which may be substituted with halogen, CF3, CN, OH, alkyl, alkenyl, alkynyl, alkoxy, amino, or nitro; phenylamino which may be substituted with halogen, CF3, CN, OH, alkyl, alkenyl, alkynyl, alkoxy, amino, or nitro; or aryl which may be substituted one or more times with halogen, CF3, CN, OH, alkyl, cycloalkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, phenoxy, phenylalkyl, amino, nitro, sulphamoyl, pipiridyl, pyrrolidinyl, CO2H, CO2- alkyl, CO-amino, or NH-CO-alkyl; and R4, R5, R6 and R7 are each independently hydrogen; halogen; amino; nitro; CN; CF3; COOH; COO-alkyl; alkyl; acyl; alkoxy; -(CH2)n,-OH wherein n is 0, 1,2, or 3; -(CH2)m-O-alkyl wherein m is 0, 1,2, or 3; -(CH2)o-O-acyl wherein o is 0, 1,2, or 3; and that if X is N then R4 is absent and that if Y is N then R7 is absent; or a pharmaceutically-acceptable addition salt thereof The compounds are useful as pharmaceuticals, for example, in the treatment of stroke, ischemia, anoxia, migraine and psychosis.

Affiliated with

Also associated with

Rating

Imidazole compounds, their preparation and use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Imidazole compounds, their preparation and use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Imidazole compounds, their preparation and use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1843431