C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/10 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) C07D 235/30 (2006.01) C07D 401/10 (2006.01) C07D 403/10 (2006.01) C07D 409/10 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2112081
The present invention discloses compounds of the formula (see formula I) or a pharmaceutically-acceptable addition salt thereof wherein R' and R" independently of each other are hydrogen or alkyl, or R' and R" together form a 3 to 6 membered alkylene chain; one of R1 and R2 is aryl which may be substituted one or more times with halogen, CF3; CN, OH, alkyl, cycloalkylalkyl, alkenyl, alkynyl, alkoxy, amino, nitro, sulphamoyl, tetrazolyl, CO2H, CO2-alkyl and the other of R1 and R2 is hydrogen, halogen, alkoxy, amino or alkyl; and R4; R5, R6 and R7 independently of each other are hydrogen; halogen, amino, nitro, CN; OH; CF3, alkyl or alkoxy; and n is 0 or 1; provided that neither of R1 and R2 is phenyl or substituted phenyl when n is 0. The compounds are useful as pharmaceuticals, for example, in the treatment of ischemia, anoxia, migraine and psychosis.
Axelsson Oskar
Nielsen Elsebet Ostergaard
Peters Dan
Neurosearch A/s
Perley-Robertson Hill & Mcdougall Llp
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