Imidazole derivative

Details Imidazole derivative Imidazole derivative

C - Chemistry, Metallurgy

07

D

C07D 233/84 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) C07D 233/54 (2006.01) C07D 233/56 (2006.01) C07D 233/64 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 409/04 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2200316

An imidazole derivative represented by general formula (I) or a salt thereof, having the effect of specifically inhibiting the growth of HIV as a pathogenic virus and being reduced in toxicity. In said formula R1 represents hydrogen, C1-C20 alkyl, C2-C7 alkenyl, C4,-C12 cycloalkylalkyl, etc.; R2 represents C1-C6 alkyl, C1-C6 aryl, hydroxyiminomethyl, hydrazonomethyl or -(CH2)n-R4 (R4 being halogeno, alkoxy, hydroxy, etc.; and n being an integer of 1 to 3); R3 represents substituted or unsubstituted C1-C6 alkyl; X and Y represent each independently hydrogen, C1-C3 alkyl, halogeno, or nitro; and Z represents S, SO, SO2 or CH2.

Dérivé imidazole représenté par la formule générale (I), ou sel de ce dérivé, exerçant une activité inhibitrice spécifique contre le développement du VIH en tant que virus pathogène tout en présentant une faible toxicité. Dans cette formule, R<1> représente hydrogène, alkyle C1-C20, alcényle C2-C7, cycloalkylalkyle C4-C12, etc.; R<2> représente alkyle C1-C6, acyle C1-C6, hydroxy-iminométhyle, hydrazonométhyle ou -(CH2)n-R<4> (R<4> étant halogèno, alcoxy, hydroxy, etc., et n correspondant à un entier pouvant aller de 1 à 30); R<3> représente un alkyle substitué ou non substitué C1-C6; X et Y représentent indépendamment hydrogène, alkyle C1-C3, halogéno ou nitro; et Z représente S, SO, SO2 ou CH2.

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