Imidazole derivative and their use as peripherally-selective...

Details Imidazole derivative and their use as peripherally-selective... Imidazole derivative and their use as peripherally-selective...

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/4164 (2006.01) A61P 43/00 (2006.01) C07D 233/84 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2501819

Compounds of formula (I) and a method for their preparation are described, where X is CH2, O or S, and n is 1, 2 or 3, with the proviso that if X is CH2, n is not 1. The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.

L'invention concerne des composés de formule générale (I) et un procédé de préparation de ceux-ci, dans laquelle X est CH¿2?, O ou S, et n vaut 1, 2 ou 3, sous réserve que si X est CH¿2?, n ne vaut pas 1. Les composés de l'invention présentent des propriétés pharmaceutiques potentiellement intéressantes pour le traitement de troubles cardiovasculaires de type hypertension et insuffisance cardiaque chronique.

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