Imidazole derivatives

Details Imidazole derivatives Imidazole derivatives

C - Chemistry, Metallurgy

07

D

260/280, 260/305

C07D 233/56 (2006.01) C07D 403/00 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1174680

ABSTRACT OF THE DISCLOSURE Compounds of the general formula: Image (I) and acid addition salts thereof; in which Ar and Ar1 which may be the same or different, each represent an aromatic radical which may be susbtituted one or more times by substit- uents selected from the following: halogen; carboxy; lower alkyl; carboxyalkyl; lower alkoxy; cyano; alkylenedioxy; carboxamido; aralkoxy; di-lower alkylamino; aryloxy; nitro; and trihalomethyl; lower alkyl sulphonyl provided that one of the groups Ar and Ar1 carries at least one alkoxy, alkylenedioxy, carboxy or carboxy- alkyl substituent; and Alk1 and Alk2, which may be the same or different, each represent an alkylene group containing from 1 to 8 carbon atoms which may be substituted one or more times by lower alkyl; X and Y which may be the same or different represent oxygen, nitrogen or sulphur; and in which the imidazole ring may be substitued by one or more lower alkyl substituents have antithrombotic activity. A representative compound is 1-[2-[(4-methoxyphenyl)methoxyl-3-[(4- methoxyphenyl)methoxylpropyl]-1H-imidazole. The compounds are useful as antithrombotics.

400868

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