Imidazole derivatives

Details Imidazole derivatives Imidazole derivatives

C - Chemistry, Metallurgy

07

D

260/280, 260/305

C07D 233/60 (2006.01) C07D 401/00 (2006.01) C07D 405/04 (2006.01)

Patent

CA 1244032

ABSTRACT An imidazole derivative of the formula: Image wherein each of R1 and R4 is a hydrogen atom or a lower alkyl group; each of R2 and R3 is a nydrogen atom, a halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group an araIkyloxy group, a nitro group or an amino group; A is -O-, -S-, -CH=CH- pr -OH=N-; Z is an aryl group, a thienyl group, a pyridyl group or a furyl group, in which definition these aromatic (hetero- cyclio) rings may have 1 to 3 substituents, each substituent boing independently selected from a halogen atom, a lower alkyl group, a cyclic alkyl group, a lower alkoxy group, a hydroxyl group, a carboxyl group, a lower alkoxycarbonyl group, a carboxy-lower-alkoxy group, a di-lower-alkylamino-lower-alkoxy group and a nitro group; and a pharmaceutically acceptable acid addition salt thereof, a method for preparing the same and a pharmaceutical composition containing such compound. Such compounds have inhibitory activities on biosynthesis of thromboxane A2, inhibitory activities on platelet aggregation, vasodilative activities and protective effects on liver disorders.

435834

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