Imidazole derivatives and salts thereof, their synthesis,...

Details Imidazole derivatives and salts thereof, their synthesis,... Imidazole derivatives and salts thereof, their synthesis,...

C - Chemistry, Metallurgy

07

D

260/315.25, 260/

C07D 233/56 (2006.01) C07D 403/10 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1212115

ABSTRACT OF THE DISCLOSURE Compounds of the formula:- Image (I) wherein R is (Hal)m wherein Hal represents a halogen atom and m is 1 or 2, or R is-(B1)n1W1 wherein B1, n1 and W1 are as defined below; W and (when present) W1, which may be the same or different, each represents a carboxyl, esterified carboxyl, amide, N-C1-4 alkyl-amide, N, N - di- (C1-4 alkyl)-amide, nitrile, aldehyde, amino, hydroxymethyl, or tetrazolyl group; n and (when present)n1 which may be the same or different, are each 0 or 1; and A, B and (when present)B1, which may be the same or different, each represents a straight chain or branched C1-3 alkylene or C2-3 alkenylene group. These compounds have been found to possess potent and selective inhibitory activity against thromboxane synthetase which renders the compounds useful in the treatment or prophylaxis of thrombo-embolic disorders.

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