C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/06 (2006.01) A61K 31/4178 (2006.01) A61K 31/4439 (2006.01) A61P 25/00 (2006.01) A61P 25/22 (2006.01)
Patent
CA 2531210
The present invention relates to imidazole derivatives of the general formula (I), wherein R1, R2, R3 and R4 are as defined in the description as well as pharmaceutically acceptable salts and processes for the preparation thereof. The invention also relates to medicaments containing said imidazole derivatives and to their use for the manufacture of medicaments for the treatment and prevention of mGluR5 receptor mediated disorders such as acute and/or chronic neurological disorders, in particular anxiety, or for the treatment of chronic and acute pain.
La présente invention porte sur des dérivés d'imidazole de la formule générale (I), dans laquelle R?1¿, R?2¿, R?3¿ et R?4¿ sont tels que définis dans le descriptif, ainsi que sur des sels acceptables d'un point de vue pharmaceutique et sur leurs procédés de préparation. L'invention porte également sur des médicaments contenant des dérivés d'imidazole et sur leur utilisation dans la fabrication de médicaments destinés au traitement et à la prévention de troubles induits par le récepteur mGluR5, tels que des troubles neurologiques aigus et/ou chroniques, notamment l'anxiété, ou au traitement de la douleur chronique ou aiguë.
Buettelmann Bernd
Ceccarelli Simona Maria
Jaeschke Georg
Kolczewski Sabine
Porter Richard Hugh Philip
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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