Imidazole derivatives as fructose-1,6-bisphosphatase...

Details Imidazole derivatives as fructose-1,6-bisphosphatase... Imidazole derivatives as fructose-1,6-bisphosphatase...

C - Chemistry, Metallurgy

07

D

C07D 233/00 (2006.01)

Patent

CA 2617378

Imidazole derivatives of formula (I) wherein R1, R2a, R2b, A, V and W are as defined in the description, as inhibitors of fructose-1 ,6-bisphosphatase, their preparation process and their use in the prevention or treatment of diabetes, and other diseases where the inhibition of gluconeogenesis, control of blood glucose levels, reduction in glycogen stores, or reduction in insulin levels is beneficial and diseases related to the insulin resistance syndrome.

La présente invention concerne des dérivés d~imidazole de formule (I) : où R1, R2a, R2b, A, V et W sont tels que définis dans la description, comme inhibiteurs de fructose-1 ,6-bisphosphatase, leur procédé de préparation et leur utilisation dans la prévention ou le traitement du diabète et autres maladies où l~inhibition du gluconéogenèse, le contrôle des niveaux de glucose dans le sang, la réduction des réserves de glycogènes ou la réduction des niveaux d~insuline est bénéfique et pour la prévention ou le traitement des maladies liées au syndrome d~insulinorésistance.

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