Imidazole derivatives as glutamate receptor antagonists

Details Imidazole derivatives as glutamate receptor antagonists Imidazole derivatives as glutamate receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61P 25/28 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2527315

The present invention relates to imidazole derivatives which are mGluR5 receptor antagonists and which are represented by the general formula (I): wherein R1, R 2 , R3 and R4 are as defined in the specification, to a process for the manufacture thereof, as well as to pharmaceutically acceptable salts thereof for the manufacture of a medicament for the treatment or prevention of mGluR5 receptor mediated disorders, such as acute and/or chronic neurological disorders.

L'invention concerne des dérivés imidazole qui sont des antagonistes du récepteur mGluR5, et qui sont représentés par la formule générale (I): dans laquelle R?1¿, R?2¿, R?3¿ et R?4¿ sont tels que définis dans le descriptif, un procédé permettant de produire ces dérivés, ainsi que des sels pharmaceutiquement acceptables servant à la préparation d'un médicament destiné au traitement ou à la prévention de troubles dans lesquels le récepteur mGluR5 intervient comme médiateur, tels que les troubles neurologiques aigus et/ou chroniques.

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