Imidazole derivatives as protein kinase inhibitors in...

Details Imidazole derivatives as protein kinase inhibitors in... Imidazole derivatives as protein kinase inhibitors in...

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2207404

Imidazole derivatives of general formula (I), wherein R1-R8 each independently signify hydrogen, lower-alkyl, substituted lower alkyl, lower-alkenyl, lower-alkoxy, substituted lower alkoxy, lower-alkoxycarbonyl, halogen, hydroxy, amino, mono- or di(lower-alkyl)amino or nitro, and pharmaceutically usable salts thereof are protein kinase inhibitors and can be used as medicaments, e.g. for the control of hyperproliferative disorders such as atherosclerosis, psoriasis and tumors as well as of alopecia.

Dérivés imidazoles de la formule générale (I) et leurs sels acceptables sur le plan pharmacologique. Dans cette formule, R<1>-R<8> représentent chacun indépendamment hydrogène, alkyle inférieur, alkyle inférieur substitué, alcényle inférieur, alcoxy inférieur, alcoxy inférieur substitué, alcoxycarbonyle inférieur, halogène, hydroxy, amino, mono ou di(alkyle inférieur)amino ou nitro. Ces dérivés sont des inhibiteurs des protéines kinases et on peut les utiliser en tant que médicaments, par exemple pour lutter contre les désordres excessivement prolifératifs tels que l'athérosclérose, le psoriasis et les tumeurs, de même que l'alopécie.

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