Imidazole derivatives as raf kinase inhibitors

Details Imidazole derivatives as raf kinase inhibitors Imidazole derivatives as raf kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/44 (2006.01) A61K 49/00 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2423154

Novel compounds (I) and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy wherein Ar is a group of formula a) or b).

L'invention concerne de nouveaux composés (I) et leur utilisation comme produits pharmaceutiques, en particulier comme inhibiteurs de la Raf kinase dans le traitement de maladies neurotraumatiques, du cancer, de la neurodégénérescence chronique, de la douleur, de la migraine et de l'hypertrophie cardiaque. Ar représente un groupe de formule a) ou b).

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