Imidazole derivatives exhibiting anticonvulsant activity

Details Imidazole derivatives exhibiting anticonvulsant activity Imidazole derivatives exhibiting anticonvulsant activity

C - Chemistry, Metallurgy

07

D

260/315.25

C07D 233/54 (2006.01) C07C 45/46 (2006.01) C07C 49/80 (2006.01) C07C 49/813 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1116611

ABSTRACT Imidazole Derivatives There are provided imidazole derivatives I and pharmaceutically acceptable acid addition salts thereof: Image I In the formula, R4 = 1-or 2-naphthyl, optionally Cl, Br, or I substituted; 1,2,3,4-tetrahydro-6-naphthyl; 3-duryl, optionally 6-substituted by Cl, Br, I, NO2, CH3 or benzyl; mesityl; phenyl 2-, 3- or 4-substituted by OH, NH2, NO2, CH3CONH, phenyl, phenoxy, cyclohexyl, phenylthio, benzylthio, C1-C6 alkyl or C1-C6 alkylthio; 4-bibenzylyl;3,4-dihydroxyphenyl, n = 0, 1, 2 and (a) R = H, C1-C6 alkyl, phenyl R1 = H, C1-C6 alkyl, phenyl one of R2 and R3 = H the other of R2 and R3 = H, OH, benzoyloxy, C2-C7 alkanoyloxy, N-(C1-C6 alkyl)-carbamoyloxy, N,N-[di- (C1-C6)alkyl]-carbamoyloxy, but if R2=R3=H then R=R1=H, or (b) R = H, C1-C6 alkyl, phenyl R1= H, C1-C6 alkyl, phenyl R2+R3=0, or Image . The compounds I are anti-convulsivants. Methods for making the compounds are disclosed.

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