Imidazole derivatives having 5-ht3 receptor antagonist activity

Details Imidazole derivatives having 5-ht3 receptor antagonist activity Imidazole derivatives having 5-ht3 receptor antagonist activity

C - Chemistry, Metallurgy

07

D

167/208, 260/305

C07D 233/64 (2006.01) A61K 31/415 (2006.01) C07D 403/06 (2006.01)

Patent

CA 1310960

- 1 - Abstract Compounds of formula (I) and pharmaceutically acceptable salts thereof: Image (I) wherein R1 and R2 are independently hydrogen or C1-6 alkyl; Z is a group of sub-formula (a), (b), (c), (d) or (e): (a) Image (b) - 2 - (c) Image (d) wherein xa to xd are selected from hydrogen, halogen and hydroxy; R3 is hydrogen and R4 is hydrogen or C1-6 alkyl, or R3 and R4 together are a bond; R5 to R10 are independently selected from hydrogen or C1-6 alkyl; and R6 together with R4 may be C2-7 polymethylene when R3 is hydrogen, or R9 and R10 may together be C2-7 polymethylene; having 5-HT3 receptor antagonist activity, processes for their preparation and their use as pharmaceuticals.

593777

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